Antibiotics

Example: Antibiotic class: β-lactam

  • Includes cephems, carbacephems, penems, carbapenems, and monobactams
  • Comprises first-line and last-resort therapies
  • Resistance to single-agent therapy is common

Cannabinoids have demonstrated functionality as anti-bacterial agents

  • Pro-apoptotic
  • Stimulates ROS production
  • Normalizes the inflammatory microenvironment

Multi-agent therapy may address bacterial resistance issues

  • Potential for activity against resistant β-lactamase producing organisms
  • Potential for slower rate of new resistance development
  • Potential for lower therapeutic dose to achieve equivalent efficacy

Antiprotozoal

Example: Ivermectin + Cannabidiol

  • Includes antimalarials, antiprotozoal, antiamoebics, antigiardials, trypanocidals, antileishmanials, anti-toxoplasmas, ectoparasiticides and anti-trichomoniasis.
  • A claim for the conjugation of one to four cannabinoids to one antiprotozoal molecule.

Cannabinoids have demonstrated functionality as antiprotozoal agents

  • Pro-apoptotic
  • Stimulates ROS production
  • Normalizes the inflammatory microenvironment
  • Inhibits growth of new organisms by breaking protein chains in cell walls

Platinum Agents

Example: Cisplatin + Cannabidiol

  • Carboplatin, Cisplatin, Oxaliplatin, Eptaplatin, Lobaplatin, Nedaplatin
  • Platinum-containing agents are also first-line and salvage therapies
  • Platinum-containing agents are used to treat a wide range of cancers including breast, colon, lung, and ovarian cancers

CBD has demonstrated efficacy in glioblastoma (GBM)

  • Pro-apoptotic
  • Inhibits glioma genesis
  • Stimulates ROS production
  • Normalizes the inflammatory microenvironment
  • Activates receptors implicated in inhibiting drugtransport activity (proposed mechanism for enhancing sensitivity to chemotherapy)